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10.1046/j.1365-313X.2003.01943.x 57 KlodmannJ.SenklerM.RodeC.BraunH
Vitamin B12 is a vital nutrient
PC-specific transfer protein and non-specific lipid transfer proteins may play a role, but animal studies suggest that neither accounts for the entirety of PC movement (Vance 2014)
Oral B12 works for many people, but it relies on digestion and absorption in the gut
As of 2024, there are small studies to suggest that topical or oral formulations of glutathione can help reduce melasma severity
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