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The proteomes were then incubated with catalytically active or dead X(PC) at a 1:50 protease:sample ratio for 16 h at 37 C with rotation
If additional validation of acetylcarnitine is carried out in a follow-up study, taking into account the larger sample size, controlled subject variables, antidepressant type, and heterogeneity due to pharmacomechanism, the potential of acetylcarnitine as a biomarker for diagnosing depression and remission status will be further elucidated
Additionally, the time required to complete the enzymatic activity measurements was prolonged, and the method needed to be more easily adaptable to microplate readers due to the necessity of protein precipitation
59, S58S62
Shorter cycles will see proportionally smaller weight-change endpoints than the full trial-length numbers
Although carnitine levels are low in heart tissue in those with chronic heart failure, carnitine blood levels may be increased because of leakage from damaged heart cells and altered carnitine metabolism [49]
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