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doi: 10.1177/0333102414544976 160
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2.4 Measurement of cAMP production HEK293-SNAP-GLP-1R cells were resuspended in serum-free medium and treated at 37C with indicated concentration of agonist for 30 min
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Comparison with previous studies The SUSTAIN 9 (Semaglutide once weekly as add-on to SGLT-2i therapy in T2DM) and SURPASS-1 (Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist Tirzepatide in patients with type 2 diabetes) trials demonstrated that both SGLT2i and GLP-1RAs reduced HbA1c and body weight levels compared with placebo in patients with a history of medical treatment for diabetes ( Safety outcomes The SUSTAIN-9 trial demonstrated an association between SGLT2i use and genital and urinary tract infections ( Discrepancies in the SGLT2i or GLP-1RA type and dosage across studies may have influenced the results
This refractory fraction of CAD, especially given its procedure-resistant microvascular nature, requires urgent development of pharmacological adjuncts to the current armamentarium
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