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JAMA Psychiatry 72 , 603611 (2015)

In 1993, Nauck et al

ETDs between oral semaglutide and comparators were generally consistent across background medication subgroups within each trial

Therefore, interventions targeting the gut microbiota may increase the levels of BH4 in the body, which can be beneficial for human health, especially for patients with congenital biopterin deficiency