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This can create a high-stakes environment where a small number of asset-indications can lift ROI, but with greater competition and sensitivity to clinical, regulatory, or market access shocks affecting those specific programs

Ethics declarations Competing interests KGW and VJNB are co-founders and shareholders of Aprea Therapeutics AB, a company that develops novel p53-based cancer therapy

l-dopa) can cross the BBB and reach brain tissue via l-type amino acid transporter-1 (LAT-1), the member of solute carrier (SLC) family present at the brain endothelium and diverse brain cells [6]

"The more loss-and-gain and loss-and-gain cycles that you've gone through in your past experience, the more your body may be prone to rebound weight quicker," Dr

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