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Antibody-mediated activation of the FGFR1/Klotho complex corrects metabolic dysfunction and alters food preference in obese humans

The presence of GLP-1 receptors in brain tissue and preliminary research findings have opened new avenues of investigation into potential neurological applications, particularly for Alzheimer's disease and related dementias

However, similar findings have not been observed in non-human primate studies, even at doses far exceeding typical human exposure

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Glucagon-like peptide-1 receptors in nucleus accumbens, ventral hippocampus, and lateral septum reduce alcohol reinforcement in mice