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Como segunda lnea se recomienda el uso de laxantes de tipo secretagogo, como son el caso de lubiprostona a dosis de 24g por va oral cada 12horas o linaclotide a dosis de 145g por va oral cada 24horas, prefirindose este ltimo por la asociacin de lubiprostona, con nusea como efecto adverso

The primary risks include bile duct stones or obstruction, compounded gastrointestinal side effects (nausea, diarrhoea), and pancreatitis

however, this inhibitory effect diminishes when concentrations increase to 50100 nM [60]

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E., Lind, Y., Eulaers, I., Hellstrm, P., Dietz, R., Persson, S., Bossi, R., & de Wit, C

This variation in sample concentration was necessary due to the limited amount of Synechococcus elongatus DNA that was recovered from a laboratory grown culture