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In view of these mechanisms, combination therapy strategies can overcome drug resistance through multitarget synergy, regulating the TME, overcoming redox homeostasis, improving drug efficacy, and effectively reversing drug resistance
Research gaps remain regarding optimal concentrations and timing in different tissue types
PMID: 29 RemiganteA.MorabitoR.MarinoA
Valproic Acid Side Effects Valproic acid is an anticonvulsant drug that can reduce the bodys carnitine levels, potentially resulting in high ammonia levels, and brain or liver damage
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