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Absorption depends on gut health, so they often work slower than injections and may not be effective for everyone

While B12 supplements benefit those with deficiencies, most people without a deficiency wont see additional benefits from taking extra oral vitamins or injections

The dose needed depends on how severe the deficiency is and the persons health

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The most important factor is consistency of timing and route day to day, since the mechanism works cumulatively rather than as an acute event to time around a meal

Patients on Specific Medications: Certain medications, like proton pump inhibitors or metformin, can interfere with B12 absorption, making monitoring and supplementation necessary