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J Physiol Pharmacol 2011;62(3):327-34

Furthermore, a correlation was observed between homocysteine and B12 levels and hyperactivity

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These changes can cause oxidative modifications to reactive thiols of structurally- or functionally-critical proteins, such as transcription factors 43 , signal transduction molecules 44 or metabolic enzymes 45 , and thereby evoke cellular defense mechanisms against oxidative damage 46