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4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release
This yields the active dimeric enzyme structure
Scratch assays demonstrated concentration-dependent enhancement in fibroblast migration, achieving 88% wound closure at 32 g/mL within 24 h
GHK-Cu is reported to influence a large number of genes and to accelerate epithelialization in wound models, but these findings describe biological activity, not a validated human safety margin
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