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Critics, including the FDA's own scientific staff, argue that insufficient evidence exists to ensure these compounds are safe for human use
Back Drucker, DJ, Mojsov, S, Habener, JF (25 July 1986) 'Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene', Journal Biological Chemistry , 261/21, 9637-43
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IGF-1 availability is tightly regulated by the so-called insulin- like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF- 1R) [7]
