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As mentioned above, there is some incidence of a phenomenon referred to as a post-injection flare wherein the injection of fluid into the knee stretches the knee capsule and induces an initial inflammatory pain response that can last for a day or so

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A systematic review and meta-analysis published in eClinicalMedicine found that discontinuing GLP-1 receptor agonist treatment led to an average weight regain of 5.63 kg and 5.81% of body weight across all patients studied

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They help separate clinical decision-making from enthusiasm and marketing