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Interestingly enough, in 6-OHDA rats, the dual GLP-1/GIP agonist (DA5-CH), in addition to promoting the survival of dopaminergic neurons, was able to reduce the levels of monomer and oligomers of -synuclein, thus providing a wider neuroprotective effect [53]
Change history 17 June 2026 In the version of this article initially published online, there were duplication errors in the Extended Data Fig
Cell 16 , 34253437 (2005)
In practice, the GLP-1 and GIP components counteract this effect
In the SUSTAIN FORTE clinical trials, participants in the semaglutide (Ozempic) group showed an average reduction of 2.2 percentage points in the HbA1c levels with a 2 mg weekly dosage and 1.9 percentage points with a 1 mg weekly dosage of semaglutide after 40 weeks
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