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The S9 system can be more effective in qualitative research, and some metabolites that undergo phase I metabolism and then phase II metabolism can be found to form specific metabolites, which are often not easily found in the in vitro research system of microsomes or cytosols (Wang et al., 2020)
Sci.U.S.A
Intrauterine hyperandrogen exposure has been proposed as a key factor causing the reprogramming of multiple genes contributing to the development of PCOS, which affects the hypothalamus-pituitary axis and metabolic disturbance, increasing LH secretion and abdominal fat accumulation and elevating insulin resistance risks at puberty and adolescence [1]
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