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HCPCS code J0178 is the Medicare Part B billing code for a 1 mg unit of intravitreal aflibercept, the anti-VEGF drug sold as EYLEA

The standard regimen involves 1 mg (1000 g) administered intramuscularly on alternate days until there is no further improvement in symptoms, followed by maintenance injections of 1 mg every two months

Off-label use means the medication is being used in a manner not specifically approved by the FDA.

All injections were performed under general anesthesia using ultrasound guidance by a trained physiatrist under sterile conditions

[114] Methyltransferases Methyl (CH 3 ) group transfers between two molecules

Rotate injection sites (abdomen, thighs, upper arms) to reduce local irritation and prevent lipohypertrophy [8]