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doi: 10.1186/s12974-021-02309-6 140 WuX.ZhaoJ.YuS.ChenY.WuJ.ZhaoY
Despite the kinetic gains, proteases still lacked cleavage activity in mammalian cells and suffered from poor expression (Fig
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[23] Palatin conducted Phase II trials of intranasal bremelanotide in both female sexual dysfunction (FSD) and male erectile dysfunction (ED) but these trials were halted by the FDA in 2007, due to increased blood pressure in clinical trial subjects
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