Oral B12 supplements have to survive your stomach acid and get absorbed through your gut lining first
AICAR is the other non-peptide small molecule in this batch and raises the same point from a different direction, being a nucleoside whose characterisation requirements are equally unlike a peptide's
When NNMT runs hot, less precursor gets recycled back into NAD+
Other areas for focus in the past and more recently have been Short-term Sleep Aids, Pain Management (e.g., certain medicines for migraine or joint pain), Skin Conditions (e.g., treatments for acne, eczema, and psoriasis) and Womens Health Conditions (e.g., treatments for heavy periods or intimate fungal infections) Again, it is frustrating here for people with PA to see that these chemical drug solutions are freely available while, for them, a life changing and life saving vitamin solution is heavily restricted
Serious Complications (Very Rare): Extremely rare but possible severe side effects can include congestive heart failure in individuals with certain heart conditions, or polycythemia vera (a blood disorder)
Beef and pork are also abundant sources of B12, as are poultry and fish