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Consequences of Low NAD+ Levels Fatigue and slow recovery: Mitochondrial inefficiency leads to ATP shortages

The 2021 Akar paper in Journal of Obstetrics and Gynaecology documented anti-proliferative activity of small-molecule NNMT inhibitors in HeLa cell systems (PMID 33645410)

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Some people report a mild warmth or a light stimulant edge in the first few days, plausibly the MAO-A activity rather than the NNMT effect