When you take Vitamin C, for example, it eventually becomes "spent" after neutralizing a free radical
This Fe 2+ fuels Fenton reactions, generating hydroxyl radicals that initiate acyl-CoA synthetaselong-chain family member 4 (ACSL4) / lysophosphatidylcholine acyltransferase 3(LPCAT3)-dependent lipid peroxidation: ACSL4 activates polyunsaturated fatty acids (PUFAs, e.g., arachidonic acid, AA/ adrenic acid, AdA), and then LPCAT3 incorporates them into membrane phospholipids (phosphatidylethanolamine-arachidonic acid/ adrenic acid, PE-AA/AdA), thus making them susceptible to oxidation by lipoxygenases (ALOXs
These effects, described in animal models, were not generally observed in humans
By slowing down digestion, more gastrointestinal side effects like the aforementioned nausea, diarrhea, burping and, of course, bloating are more likely to happen
Gould NS, Day BJ
FDA scientists remain unconvinced of peptide safety and health benefits In recent years, the FDA had warned Americans about the risks of injecting peptides like BPC-157 and TB-500, both of which are set for review on Thursday