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GLP-1, binds to GLP-1R mostly in an -helix conformation with a large surface of contact with both the extra-cellular domain and the seven transmembrane domain 27,30
26% were unsure
The tripeptide modulates over 4,000 human genes (31.2% of the genome) and plasma levels decline from approximately 200 ng/mL at age 20 to less than half by age 60 (Pickart & Margolina, 2018)
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