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While genetic variants do not predict exact medication response or topiramate-semaglutide tolerability, they may highlight individuals with naturally lower GLP-1 receptor sensitivity or higher propensity for weight regain who could benefit from dual-mechanism therapy
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J., Laffan, M
Long-Term Safety and Cardiovascular Benefits Beyond weight loss, the STEP trials documented significant improvements in cardiovascular risk factors, including reductions in systolic blood pressure, improvements in lipid profiles, and decreased inflammatory markers [3]
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