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Future research should examine how sulfonylurea-induced ABC transporter modulation affects drug bioavailability, BBB function, and -amyloid clearance, potentially influencing AD risk in DM2 patients

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This point is effectively made in a recently conducted large trial, which states that, our understanding of the mechanisms of cardiovascular protection with [the GLP-1 agonist] semaglutide remains speculativeclinical benefit is [thought to be] achieved through multiple interrelated pathways. Acknowledgement of this evidence gap prompted our lab, through use of a large animal model of CAD that replicates the features of disease as it occurs in humans, to investigate the cardiac consequences of semaglutide administration

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This can cause pain, numbness, and other complications that may require medical attention

doi: 10.1016/j.bcp.2022.115384 274 HiguchiSOhtsuHSuzukiHShiraiHFrankGDEguchiS