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Metformin combined with heavy alcohol use raises the risk of lactic acidosis

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NICE guideline NG28 supports the use of GLP-1 receptor agonists as add-on therapy to metformin when specific criteria are met, including inadequate glucose control despite optimised treatment

Amounts available from foods are limited (less that 150 mg/day), and oxidative depletion can outpace synthesis

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NAC also has applications in preventing or diminishing liver and kidney damage due to its antioxidant and anti-inflammatory properties.[15]