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It is more prevalent in Caucasian males of European descent, Persian people of the Jewish community, and a subset of Alaska Natives (Trujillo & West, 2022)

Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors

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According to Figure 1F and Figure S4A , no significant changes of the absorbance can be observed without either glucose or GSH, suggesting that glucose and GSH are both indispensable for the generation of OH, which two are essential for the generation of H 2 O 2 and Cu + Fenton agent, respectively

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It can be a sign of skin disease, infection (such as onychomycosis) or tissue injury