It can support metabolic control
It works primarily by stimulating insulin release, suppressing glucagon secretion, slowing gastric emptying, and increasing a feeling of fullness after eating
Semaglutide May Be the Better Starting Point If: You are new to GLP-1 therapy and want to start with the more established option You have strong cardiovascular risk factors (SELECT trial data is robust) You are sensitive to GI side effects and want to titrate conservatively Cost is a primary concern (compounded semaglutide is widely available) Tirzepatide May Be the Better Choice If: You have been on semaglutide and have plateaued You have type 2 diabetes or significant insulin resistance You want to maximize total weight loss potential You tolerated semaglutide well and are ready for a more potent option The right choice depends on your labs, your health history, your previous medication experience, and your goals
Starting dose, titration schedule, side-effect management, and whether youll come in for injections or administer them at home
Just like high blood pressure and high cholesterol, where we do not stop medications once a person reaches the target, it is not recommended to stop GLP-1 medications once a person has reached their goal weight," says Cynthia Odogwu, M.D
Quality can vary significantly between compounding pharmacies