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A third widely-cited paper (McCoy 2013, PMID 23055539) the source of the often-repeated "seven orders of magnitude more potent than BDNF" line carries a 2021 Expression of Concern

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Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM

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6 Low NAD+ levels are linked to fatigue, insulin resistance, frailty, and neurodegenerative disorders like Alzheimers

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This is consistent with the published epithalon research to date

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