A third widely-cited paper (McCoy 2013, PMID 23055539) the source of the often-repeated "seven orders of magnitude more potent than BDNF" line carries a 2021 Expression of Concern
The presence or absence of nausea, vomiting, or diarrhea does not determine weight loss success, and the medication remains highly effective even in users who experience minimal to no gastrointestinal symptoms
Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM
It regulates inflammatory pathways without the immunosuppressive side effects that make long-term steroid use problematic for eczema patients
6 Low NAD+ levels are linked to fatigue, insulin resistance, frailty, and neurodegenerative disorders like Alzheimers
This is consistent with the published epithalon research to date