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Most people report problems such as stomach discomfort, nausea, vomiting, or diarrhea

Whether the additional glucagon receptor activity of retatrutide contributes to a higher rate of gastrointestinal side effects compared with GLP-1 monotherapy has not yet been established in head-to-head studies, and any such comparison should be interpreted cautiously

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The hormonal imbalances caused by obesityincluding insulin resistance, elevated androgens, and disrupted leptin signallingcan significantly affect the hypothalamic-pituitary-ovarian axis