112 Moreover, YAP, a crucial transcriptional co-activator, also undergoes lactylation and enhances its nuclear localization and subsequent interaction with TEAD, thereby collectively promoting the expression of Hippo pathway target genes
Journal of Pharmacology and Experimental Therapeutics via PubMed (PMID 25187433), 2014 AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway (animal study not human evidence)
The lipid-modifying effects should be considered as part of a broader cardiometabolic benefit profile rather than a primary indication for cholesterol management
& Riley, B
Goiter rate, serum thyrotropin, thyroid autoantibodies and urinary iodine concentration in Tehranian adults before and after national salt iodization
The lack of a warning does not guarantee a drugs safety, effectiveness, or appropriateness for all patients or specific uses