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The shelterin complex shelters the telomere-loop (t-loop)In face of end-replication problem faced in telomere elongation with progressive cell divisions the components of shelterin complex destabilize and expose the t-loop eventually detected as a DSB, and triggers the DDR

Analytical Characterisation Each batch is analysed using: HPLC for purity assessment Mass spectrometry (MS) for molecular weight confirmation Quality Assurance Batches are produced under controlled laboratory conditions and evaluated against predefined quality criteria to ensure consistency, identity, and purity

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Vitamin B12 is generally considered safe

BMRB codes of previously published resonance assignments used in this study are 50398 (human FOXO4 FH domain), 50402 (human FOXO4 CR3), 51125 (human p53 TAD2), 51124 (human p53 194), and 51753 (human p53 DBD)

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