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Chronic infections and illnesses : Long-term health conditions can strain the HPA axis, including by disrupting gut health linked to hormone production

For autoimmune patients who also have metabolic syndrome, these changes address a significant contributor to their overall inflammatory burden

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When skin has been stretched by excess weight over months or years, the collagen and elastin fibers that provide elasticity become permanently damaged

This is because the liver partly overlies the stomach and obesity can cause it to become enlarged