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Investigation of carboplatin sensitivity in OVCAR5 parental and OVCAR5 CBPR cells Following multiple cycles of carboplatin treatment, cytotoxicity assays confirmed a fourfold increase in IC 50 of carboplatin in OVCAR5 CBPR cells compared to OVCAR5 parental cells (Additional file 1: Fig
IDO1 is the rate-limiting enzyme in tryptophan metabolism, and Kynurenine is an IDO1-mediated tryptophan metabolite [189]
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