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Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)
We recently described the cell-penetrating peptide FOXO4-DRI as a senolytic drug 5
MOTS-c is a mitochondrial derived peptide studied for endurance and metabolic recovery
It upregulates genes associated with tissue repair and regeneration while downregulating genes associated with inflammation and tissue destruction
It's thinner, has fewer oil glands, and often shows aging signs earlier than the face
Hindle SJ, Munji RN, Dolghih E, Gaskins G, Orng S, Ishimoto H, et al
