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Users should not expect the appetite reduction that comes with compounds like semaglutide or tirzepatide

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As a result, the science remains stuck in preclinical models while public interest accelerates at a rate far ahead of the actual evidence

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17 In addition to these findings, the SUSTAIN-6 trial also showed that semaglutide can offer a significant reduction in the risk of new or worsening nephropathy including persistent macroalbuminuria, increase in serum creatinine or the need of renal replacement therapy