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Clinicians managing patients on testosterone who wish to explore retatrutide should: Consult the relevant clinical trial protocols if the patient is enrolled in a study Seek specialist endocrinology input before initiating any off-label or investigational combination Document clinical rationale clearly , obtain informed consent, and follow GMC Good Practice in Prescribing and Managing Medicines and Devices guidance when considering unlicensed or investigational treatments Until formal guidance is available, clinical decision-making should be guided by individual patient riskbenefit assessment, informed consent, and regular monitoring

Record the date, time, dose, injection site, and any observations

Adv Gerontol 2022;12:1438

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A 2025 systematic review of 36 studies confirmed BPC-157 improved structural and biomechanical outcomes in ligament, tendon, muscle, and bone injuries