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Trends Endocrinol Metab 30(9):578589

This review summarizes recent molecular studies that elucidate the role of HIV-1-related factorssuch as the viral proteins trans-activator of transcription (Tat), gp120, and Vpr, HIV-1 RNAs, and associated microRNA and long non-coding RNAs and extracellular vesiclesin microglial activation through mechanisms including cellular senescence, ferroptosis, defective mitophagy, NLR family pyrin domain containing 3 activation, and NF-B pathway modulation

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B12 deficiency is quite common in both the US and UK, affecting around 6% of people aged under 60, and nearly 20% of those 60 and over

its activation would lead to intracellular Na + retention, thus enhancing Na + /Ca 2+ exchange and H 2 O reabsorption (95, 96)