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Improved metabolic health on semaglutide is typically a positive factor in insurance underwriting, not a negative one
For instance, in individuals with melanocortin receptor 4 (MC4R) deficiency (a genetic model of obesity), heightened activity in the ventral and dorsal striatum has been observed in response to palatable foods compared to individuals without MC4R mutations
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They recognize that clinical trials showed modest effects (average 2.6 kg over 12 weeks in responders), appreciate that individual response varies significantly, commit to proper nutrition and exercise foundations, and accept that the peptide is used for research purposes under medical supervision
Endogenous GLP-1 is rapidly degraded by the enzyme Dipeptidyl Peptidase-4 (DPP-4) , with an effective plasma half-life of only ~2 minutes after intravenous injection ( [39] ) ( [40] )