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Indeed, combination of exome, transcriptome, and metabolome analyses of multiple NSCLC cell lines also clearly demonstrated that remarkable enhancement of glutamate excretion, cystine uptake, and glutathione synthesis is a striking and reproducible feature of NRF2-addicted cancer cells (Saigusa et al

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the upregulation of -galactosidase activity in lysosomes induces positive staining of senescent cells [34]