GLP-1 receptor agonists caused thyroid C-cell tumors in rodent studies at all dose levels tested (Wegovy prescribing information, Novo Nordisk, 2021)
Thats just our culture, to not force people to do things. HR Director, large manufacturer Were certainly keeping an eye on our cost and then well reevaluate every year
The highest concentration of L-cells is found in the ileum and large intestine, though smaller numbers are present in the duodenum and jejunum
doi:10.1001/archotol.1993.01880180068013
MC3R: Found in various tissues, including the brain and placenta, MC3R has been implicated in regulating appetite and maintaining energy homeostasis
Neurosci Lett 107:251255 Mitsushima D, Sano A, Takahashi T (2013) A cholinergic trigger drives learning-induced plasticity at hippocampal synapses