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Pancreatitis can develop at any time during treatment, but most cases occur within weeks to months of starting the medication
Both alcohol and retatrutide's GI effects increase fluid loss
Barger et al
Additionally, GLP-1 may increase pyloric sphincter tone, creating a functional barrier that further slows gastric outflow
It stimulates brown adipose tissue, which burns calories to generate heat rather than storing them as white fat
Oral GLP-1 therapies are viewed as a major future growth segment because they can improve access and reduce injection-related barriers
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