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The only therapeutic approach currently in clinical trials is AAV2-BDNF gene therapy, which requires neurosurgical implantation
doi: 10.1073/pnas.0804373105 47 PasquadibisceglieABonaccorsi Di PattiMCMusciGPolticelliF
TG and LS wrote the paper
The coverage losses are massive
Long-Term l-Serine administration reduces food intake and improves oxidative stress and Sirt1/NFB signaling in the hypothalamus of aging mice
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