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Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T (2019) Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimers disease

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The two compounds work on entirely separate receptor systems and metabolic pathways

While the choice can be like "splitting hairs," there are key differences in how they work

The diverse roles of reactive astrocytes in the pathogenesis of amyotrophic lateral sclerosis