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A pea-sized amount, applied at night on clean, dry skin, is usually plenty

In the present study, we combine untargeted proteomics with an optimized tear fluid proteomics workflow, including in-strip protein digestion, which has previously identified over 3000 unique proteins in tear fluid 21

FIGURE 8 The aforementioned abnormalities at the molecular level (downregulation of the Nrf2/HO-1 axis and GPX4) and subcellular structural level (neuronal somata and mitochondrial impairment) were consistent with the GSH metabolism perturbations identified by multi-omics analyses, collectively reflecting oxidative stress-associated damage in the hippocampus during SAE

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Importantly, it also inhibits hepatic NAT2 and triggers ferroptosis an iron-dependent cell death process causing acute liver injury in mice

doi: 10.1007/978-981-99-0361-0_9 280 MatacchioneGValliDSilvestriniAGiulianiASabbatinelliJGiordaniCet al