Inhibition of SGLT2 reduces sodium reabsorption in the proximal tubule and enhances Na + delivery to the macula densa, promoting finally the TGF activation with consequent afferent arteriole vasoconstriction and reduction of the single-nephron-glomerular-filtration-rate ( Figure 1 )
In this way, a much higher amount reaches the blood and tissues than with oral supplements
The study included 56 patients (49 women), making it relatively small
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Overall, any conclusion that a given antibody or serum is effective in mediating ADCC needs to be carefully examined in the context of the assay used