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The agency does not review compounded GLP-1 medications for safety, and said it has received "adverse event reports" from patients who have used compounded semaglutide medications

doi: 10.1016/j.molmet.2019.09.010 3 CampbellJEDruckerDJ

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Finally, the biology of non-response and therapeutic resistance - including the role of gut microbiome composition, adipose tissue dysfunction phenotypes, and genetic determinants of drug metabolism - represents a frontier for translational investigation to improve patient outcomes

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