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10.1016/j.devcel.2022.01.004 112 LiaoM.ZhangT.WangH.LiuY.LuM.HuangJ.et al (2017)

Yes, this can happen under certain conditions

These reactions include permanent scarring, skin deformities, cysts, severe infections, etc (1)

Samples were mounted onto glass slides using water as a medium and investigated under a Leica (DMI 6000 CS AFC Bino inverted microscope) TCS SP8 instrument

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Systemic symptoms: Fever, chills, or feeling generally unwell alongside local symptoms may indicate a more serious infection requiring urgent assessment