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Owing to the overproduced H 2 O 2 and GSH in tumor cells, TeNW can selectively eliminate cancer cells while normal cells survive (Figure 1J)
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The field has evolved from the 2-minute half-life of native GLP-1 to engineered analogs that persist for a week a 5,000-fold improvement achieved through fatty acid conjugation, D-amino acid substitution, cyclization, and depot formulations
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