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Frontiers in Pharmacology, 14 , 1147414

S2 additional material).7,8 The incidence of PsO and HS has increased in western countries in recent decades.9,10 Obesity has increased in parallel, and could be responsible, at least partially, for the aforementioned increase.8 Psoriasis and obesity The prevalence of obesity is higher among patients with PsO than in the general population.1118 In addition, obesity increases the risk of PsO,6,19,20 the incidence of which could be twice as great in patients with grade II/III obesity compared with subjects with normal weight.21 Among the molecular mediators at the intersection between the 2 conditions are 3 adipokinesleptin, resistin, and adiponectinwhose levels impact the severity of PsO in patients with obesity.2224 Many complications associated with obesity are also associated with PsO

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This artificially synthesized analog of alpha-melanocyte-stimulating hormone (-MSH) precisely mimics the naturally produced melanocyte-stimulating hormone in the human body, directly activating the MC1 receptor in melanocytes, triggering an increase in tyrosinase activity, and accelerating the generation and transport of melanin

Its anti-inflammatory properties contribute to a more stable immune system, helping to reduce symptoms associated with autoimmune diseases