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Up to now all the prospective GPR119 agonists were plagued by low bioavailability, lack of efficacy and more importantly, cardiotoxicity which has stopped all human studies before any large scale Phase III clinical trials (239)
Additionally, if you replaced Wegovy with Mounjaro, you might need to start at the lowest dose of Mounjaro and gradually titrate up to the higher doses
237 DinarelloCA
Some studies also tested intranasal use
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