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Evidence suggests that the targeting of CAFs could have significant applications

Results from clinical trials suggest that such drugs could have potential for the treatment of asthma, which is one of the most chronic inflammatory pulmonary diseases in the world and often linked to both type 2 diabetes and obesity (Wu, Stokes Peebles)

[18] Systemic side effects may include headache, irritability, restlessness, depression, fatigue, or edema resulting from fluid retention

Metformin typically achieves A1C reductions of 1.0-1.5% as monotherapy, depending on the baseline level